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Symptoms of CIRS (Chronic Inflammatory Response Syndrome)

Symptoms of CIRS

Are you experiencing mysterious symptoms of CIRS that doctors can’t seem to explain? Do fatigue, brain fog, and unexplained body aches constantly plague you? These could be signs that you are suffering from Chronic Inflammatory Response Syndrome (CIRS). This debilitating condition, characterized by a range of symptoms of CIRS, often goes undiagnosed, leaving patients frustrated and desperate for answers

Symptoms of CIRS


Symptoms can vary from person to person, but may include:

  • Fatigue
  • Headaches
  • Brain fog
  • Difficulty concentrating
  • Memory problems
  • Sinus congestion
  • Cough
  • Wheezing
  • Shortness of breath
  • Skin rashes
  • Joint pain
  • Muscle pain
  • Digestive problems
  • Mood changes
  • Anxiety
  • Depression


Recognizing the Symptoms of CIRS

Embark on a journey of discovery with us as we reveal the hidden symptoms of CIRS, equipping you with the crucial knowledge to navigate this condition. Begin the transformative journey toward health—recognize the silent signs, embrace early detection, and seek accurate diagnosis. Take that vital first step with us and move towards a life free from the shadows of CIRS

What is Chronic Inflammatory Response Syndrome (CIRS)

Chronic Inflammatory Response Syndrome (CIRS) is a condition that occurs when the body’s immune system becomes overwhelmed and unable to regulate inflammation properly. It is often triggered by exposure to mold and other biotoxins, leading to a range of debilitating symptoms. The syndrome was first identified by Dr. Ritchie Shoemaker, who noticed a pattern of symptoms in patients exposed to water-damaged buildings.

CIRS is not a well-known condition, and many patients suffer for years without a proper diagnosis. The symptoms of CIRS can be diverse and vary from person to person, making it challenging to identify. However, by understanding the common symptoms associated with CIRS, individuals can seek the appropriate medical attention and treatment.

The link between mold exposure and CIRS

Mold exposure is a significant trigger for CIRS. When individuals are exposed to mold spores, their immune system can become dysregulated, leading to an inflammatory response. Mold produces biotoxins, which can have a detrimental effect on the body, especially in individuals who are genetically predisposed to an impaired detoxification system.

The presence of mycotoxins in the body can lead to chronic inflammation and a breakdown in various physiological processes. This can result in the development of CIRS and the subsequent onset of symptoms. It is essential to note that not everyone exposed to mold will develop CIRS. Genetic predisposition and individual susceptibility play a crucial role in determining who is at risk.

Diagnosis and testing for CIRS

Proper diagnosis and testing for CIRS are vital to ensure that individuals receive the appropriate treatment and support. Since the symptoms of CIRS can overlap with other conditions, it is essential to consult with a healthcare professional experienced in diagnosing and treating this syndrome.

Several diagnostic tools can help identify CIRS, including a thorough medical history review, physical examination, and laboratory tests. These tests may include blood work to assess inflammatory markers, genetic testing to determine susceptibility, and urine tests to detect mycotoxins and other biotoxins.

Lifestyle changes to manage CIRS symptoms

While there is no cure for CIRS, certain lifestyle changes can help manage the symptoms and improve overall well-being. This includes adopting a clean and healthy diet, reducing exposure to environmental toxins, practicing stress management techniques, getting regular exercise, and optimizing sleep hygiene.
It is also essential for individuals with CIRS to prioritize self-care and engage in activities that promote relaxation and mental well-being. This may include mindfulness practices, yoga, meditation, and engaging in hobbies or activities that bring joy and fulfillment.

The importance of early detection and intervention

Early detection and intervention are critical when it comes to managing CIRS effectively. The longer the body is exposed to mold and biotoxins, the more challenging it becomes to restore balance and alleviate symptoms. Seeking medical attention at the first signs of possible mold exposure or unexplained symptoms can prevent years of unnecessary suffering.

It is essential for healthcare providers to consider CIRS as a potential diagnosis when evaluating patients with unexplained chronic symptoms. By raising awareness and educating medical professionals, more individuals can receive timely and accurate diagnoses, leading to improved treatment outcomes.

Research and advancements in CIRS understanding

As our understanding of CIRS continues to evolve, so too does the research and advancements in diagnosing and treating this complex syndrome. Ongoing studies are focusing on identifying biomarkers, developing targeted therapies, and refining diagnostic criteria.

It is an exciting time for the CIRS community as new discoveries shed light on the underlying mechanisms of this condition. These advancements offer hope for improved diagnostic accuracy, more effective treatments, and ultimately, a better quality of life for individuals with CIRS.

Research and advancements in CIRS understanding

The following are useful links for advanced CIRS testing:

For a quantitative AI generated analysis of relative brain volumes

Neuroquant testing https://www.cortechs.ai/products/neuroquant/


For a transcriptonic analysis of inflammatory patterns:

GENIE Testing https://www.progenedx.com/genie-surviving-mold


For testing visual contrast sensitivity

VCS testing https://www.survivingmold.com/store/online-vcs-screening


For  screening of environmental conditions:

ERMI testing https://www.envirobiomics.com/product/ermi/?v=7516fd43adaa



Conclusion: Living a healthier life with CIRS

While living with CIRS can be challenging, understanding the silent symptoms and underlying mechanisms of this condition can empower individuals to take control of their health. Through early detection, proper diagnosis, and personalized treatment plans, individuals with CIRS can find relief from their symptoms and improve their quality of life.

By raising awareness and advocating for improved diagnostic protocols, we can ensure that individuals with CIRS receive the support and understanding they deserve. Together, let us unmask the hidden symptoms of CIRS and forge a path towards a healthier and happier future. Take the first step towards reclaiming your life and finding relief from the silent torment of this often misunderstood condition

Are you suffering from a mold related illness?

Many patients that suffer from chronic illnesses are actually unknowing victims of biotoxin illness. Scientific research and clinical experience has revealed that many patients suffering from diagnosed chronic diseases may have underlying immunologic responses related to biotoxin illness. In other words, if you have been diagnosed with multiple sclerosis, Parkinson’s disease, dementia, tremors, unexplained weight gain, depression, anxiety, irritable bowel syndrome, paroxysmal orthostatic tachycardia syndrome, Lyme disease, chronic fatigue syndrome, fibromyalgia, leaky gut syndrome, migraine headaches, premenstrual syndrome (PMS), polycystic ovary syndrome (PCOS), systemic candidiasis (yeast syndrome), multiple chemical sensitivities or other mysterious chronic ailments, you may actually be suffering from a form of biotoxin illness.

What is the Treatment for CIRS?

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The treatment for CIRS requires an intelligent, systematic approach that includes the following:

  • Identify that you have a case of CIRS – through a battery of tests
  • Avoid/remove the offending biological toxin from your environment
  • Use special products to remove biotoxins from your body
  • Take steps to restore control to your immune system, hormone system and nervous system through a metabolically directed functional medicine approach

Surviving Mold Protocol Certified by Dr. Ritchie Shoemaker

Dr. Rothman was introduced to the concept of mold illness and the work of Dr Ritchie Shoemaker in 2011 leading to therapeutic breakthroughs for helping these “problem” patients.

How can Dr. Michael Rothman help?

Dr. Michael Rothman is a leading expert in the diagnosis and treatment of CIRS.

Surviving Mold Protocol Certified by Dr. Ritchie Shoemaker

His approach is based on the following principles:

  • Identify and remove the source of exposure to biological toxins
  • Support the immune system
  • Detoxify the body

Specifically, Dr. Rothman's approach includes the following:

  • Detoxification therapy: This therapy uses a variety of methods to remove toxins from the body, including chelation therapy, sauna therapy, and hyperbaric oxygen therapy.
  • Immune support: This therapy uses a variety of methods to support the immune system, including supplements, diet, and lifestyle changes.
  • Biofilm removal: Biofilms are a type of protective layer that can be formed by bacteria and other organisms. Dr. Rothman believes that biofilms can play a role in CIRS, and he has developed a treatment protocol to remove biofilms from the body.

Dr. Ritchie Shoemaker’s Pioneering Work in Environmental Illness

Dr. Shoemaker has been the leading pioneer investigating mold (and other biotoxin related) illnesses since 1996. His brilliant work has paved the way for understanding the genetic and proteomic aspects of biotoxin illness. Dr. Shoemaker has written numerous studies published in peer-reviewed journals supporting the scientific proof of his methods. After practicing medicine for over 30 years, Dr. Shoemaker retired from his family medicine practice in Pokomoke, Maryland in 2013.However, he continues be in the forefront of research on biotoxin illness and is passing the torch to a new generation of doctors in The Surviving Mold Protocol. Dr. Michael Rothman is the latest doctor honored by achieving The Shoemaker Certification for treating biotoxin patients.

Adrenal Stress, graphic image example

HLA DR Susceptible Genes

  • 4-3-53
  • 11-3-52B
  • 12-3-52B
  • 14-5-52B
  • 7-2-53
  • 7-3-53
  • 13-6-52A,52B,52C
  • 17-2-52A
  • 15-6-51
  • 16-5-51

Chronic Stress Can Increase ACTH and Cortisol Levels

All Sex and Adrenal Cortex Hormones are Made From Cholesterol

Activated Macrophages increase 1,25 dihydroxy Vitamin D

Bathtub Analogy

A way to visualize biotoxin excretion with and without binding agents

Bile Resin Binding Agents

  • Cholestyramine
  • Welchol
  • Activated charcoal
  • Zeolite clay
  • Bentonite clay
  • Chlorella
  • Okra
  • Others

Factors that Affect Bile Flow

  • Decrease Bile Flow – high carb diet, excess sugar in diet, excess PUFA in diet, high estrogen, hypothyroidism, low progesterone, low testosterone
  • Increase Bile Flow – sufficient cholesterol and saturated fat in diet, normalization of thyroid metabolism, normalization of sex hormones, sufficient glycine and taurine, cholagogues (milk thistle, dandelion, turmeric, burdock, schisandra, others)
  • Note – bile salts are composed of cholesterol, taurine, glycine and lethicin

Bile Excretion is an Important Route to Eliminate
Fat Soluble Toxins Like Biotoxins

Multiply Antibiotic Resistant Coagulase Negative Staph (MARCoNS)

  • Can colonize sinuses and other body cavities
  • Highly anti-biotic resistant
  • Makes bio-film
  • Can cause systemic illness
  • Treatment must include both anti-microbials and biofilm breakers

Sunlight and Fresh Air are Vital to Your Recovery

Test and Treat for Tick Borne Diseases

  • Lyme Disease
  • Erlichiosis
  • Babesiosis
  • Bartonella
  • Rocky Mountain Spotted
  • Fever (RMSF)
  • Anaplasmosis
  • Tickborne Relapsing
  • Fever (TBRF)
  • Rickettsia
  • Tularemia
  • Powassan Disease
  • Borrelia mayonii
  • Borellia miyamotol

Consider other Sources of Toxicity

  • Chronic Mold Exposure leads to immune dysfunction which can contribute to downstream distortions in your microbiome, paving the way for:
  • Fungal overgrowth – Candida, yeast, small intestinal fungal overgrowth (SIFO)
  • Dysbiosis – small intestinal bowel overgrowth (SIBO), imbalance in bowel flora, H Pylori
  • Parasites
  • Heavy Metals

Dr. Rothman discusses the genetic and immunologic causes of mold related illnesses. He then reviews the diagnosis and treatment of these chronic, health destroying conditions known as chronic inflammatory response syndrome (CIRS), following the Surviving Mold Protocol.

To learn more about Michael Rothman MD contact us today by giving us a call at (732) 268-7663, emailing us at [email protected] or by requesting an appointment online.

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